Synthesis of Pyrrolidine Ring of Nicotine from Several C14-labeled Metabolites by Nicotiana rustica
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چکیده
منابع مشابه
Synthesis of pyrrolidine ring of nicotine from several C14-labeled metabolites by Nicotiana rustica.
The pyrrolidine ring of nicotine has been shown to be formed from ornithine, glutamic acid, and proline (l-5). Although little information is available concerning the interrelationship of these three amino acids in higher plants, Al-pyrrolinedcarboxylate (in equilibrium with glutamic semialdehyde) has been shown to be a key intermediate in their interconversion in animals and microorganisms (6,...
متن کاملMetabolism of the Methyl Group of Nicotine in Nicotiana rustica.
The methyl group of nicotine has been shown to participate in transmethylation reactions involving methionine (3) and choline (8). De novo synthesis of radioactive nicotine from nornicotine, methioninemethyl-C14 and ATP was demonstrated recently in leaves of Nicotiana alata (9). In the present study the rate of metabolism of the methyl group of nicotinemethyl-C14 ancl the rate of transmethylati...
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کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...
15 صفحه اولIncorporation of carbon dioxide and acetate into the pyrrolidine ring of nicotine.
Glutamate, a proposed precursor of the pyrrolidine ring of nicotine, was isolated and degraded after metabolism of 14C02 for 6 hours by Nicotiana rustica and Nicotiana glutinosa and after metabolism of acetate-2J4C for 2 hours by N. rustica. The 14C distribution in glutamate from N. glutinosa after 6 hours of W02 metabolism was 20.2, 14.3, 13.9, 24.4, and 26.6%, in C-l through C-5, respectively...
متن کاملThe metabolism of ring-labeled L-thyroxine-C14 in vivo.
In the past, investigators have used thyroxine labeled either with JIP" in the 3',5'-position or with C14 in the carboxyl position to study the metabolism of thyroxine in vivo. Although these studies have yielded much valuable information, our knowledge about the metabolic fate of the ring structure in thyroxine is incomplete because both the 3'5'-IJ13 and the carboxyl-C14 are rapidly removed f...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)60388-6